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K-Ras G12C-IN-12

CAS No. 1469337-95-8

K-Ras G12C-IN-12( MDK-7958 | MDK7958 | MDK 7958 | K-Ras(G12C) inhibitor 12 )

Catalog No. M12005 CAS No. 1469337-95-8

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    K-Ras G12C-IN-12
  • Note
    Research use only, not for human use.
  • Brief Description
    An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells.
  • Description
    An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells; relys on the mutant cysteine for binding and therefore do not affect the wild-type K-Ras.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MDK-7958 | MDK7958 | MDK 7958 | K-Ras(G12C) inhibitor 12
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    K-Ras(G12C)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1469337-95-8
  • Formula Weight
    449.6713
  • Molecular Formula
    C15H17ClIN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 48 mg/mL
  • SMILES
    C=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O
  • Chemical Name
    2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ostrem JM, et al. Nature. 2013 Nov 28;503(7477):548-51.
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